SELER (Super enhancer associated lncRNA directed transcriptional regulation in human cancer) is a novel database integrating large amounts of experimental and computational data to decode the regulatory functions of SE-lncRNAs in tumorigenesis. Considerable information is offered to facilitate the investigation of SE-lncRNAs. 5056 SE-lncRNAs and their associated genes have been identified by analyzing hundreds of super-enhancer datasets. More importantly, we explored their potential roles in tumorigenesis based on their expression profiles and prognostic information derived from 19 cancer types. Totally, 436 significantly differentially expressed SE-lncRNAs and 2035 SE-lncRNAs with significantly prognostic value were identified. Additionally, the relationships between SE-lncRNAs and their associated genes were further assessed by calculating their expression correlation coefficient in each cancer type. SELER is expected to improve our comprehensive understanding of the essential roles of SE-lncRNAs in tumorigenesis.